Outer Membrane Vesicle-Host Cell Interactions

作者：Jessica D. Cecil, Natalie Sirisaengtaksin, Neil M. O’Brien‐Simpson, Anne Marie Krachler · 发表于：Microbiology Spectrum · 年份：2019 · DOI：10.1128/microbiolspec.psib-0001-2018 · 被引用次数：193 · 研究领域：Bacterial Infections and Vaccines、Streptococcal Infections and Treatments、Pneumonia and Respiratory Infections

Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range of chemically diverse cargoes, including lipids and lipopolysaccharides, membrane-embedded and associated proteins and small molecules, peptidoglycan, and nucleic acids. Particularly, virulence factors such as adhesins and toxins are often enriched in OMVs. Here we discuss a variety of ways in which OMVs facilitate host-microbe interactions, including their contributions to biofilm formation, nutrient scavenging, and modulation of host cell function. We particularly examine recent findings regarding OMV-host cell interactions in the oral cavity and the gastrointestinal tract.