Microglia in Alzheimer’s disease: A target for immunotherapy

作者：Shoutang Wang, Marco Colonna · 发表于：Journal of Leukocyte Biology · 年份：2019 · DOI：10.1002/jlb.mr0818-319r · 被引用次数：108 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Alzheimer's disease research and treatments、Immune cells in cancer

Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.