SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT

作者：Fu-Rao Liu, Zebin Xia, Meichao Zhang, Jiping Ding, Yang Feng, Jianwei Wu, Yun Dong, Wei Gao, Zengwei Han, Yuanhua Liu, Yao Yuan, Dong Li · 发表于：International Journal of Biological Sciences · 年份：2019 · DOI：10.7150/ijbs.29562 · 被引用次数：39 · 研究领域：Chromatin Remodeling and Cancer、Cancer Mechanisms and Therapy、Phagocytosis and Immune Regulation

Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elucidated. Based on analysis of GEO database and immunohistochemical detection of patient-derived pancreatic cancer tissues, we found that SMARCAD1 is more highly expressed in pancreatic cancer tissues and that its expression level negatively correlates with patients' survival time. With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechanistically, we first demonstrate that SMARCAD1 induces EMT via activating Wnt/β-catenin signaling pathway in pancreatic cancer. Our results provide the role and potential mechanism of SMARCAD1 in pancreatic cancer, which may prove useful marker for diagnostic or therapeutic applications of PC disease.