Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

作者：Ettore Beghi, Giorgia Giussani, Emma Nichols, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Haftom Niguse Abraha, Mina G Adib, Sutapa Agrawal, Fares Alahdab, Ashish Awasthi, Yohanes Ayele, Miguel A. Barboza, Abate Bekele Belachew, Belete Biadgo, Ali Bijani, Helen Bitew, Félix Carvalho, Yazan Chaiah, Ahmad Daryani, Huyen Phuc, Manisha Dubey, Aman Yesuf Endries, Sharareh Eskandarieh, André Faro, Farshad Farzadfar, Seyed‐Mohammad Fereshtehnejad, Eduarda Fernandes, Daniel Obadare Fijabi, Irina Filip, Florian Fischer, Abadi Kahsu Gebre, Afewerki Gebremeskel Tsadik, Teklu Gebrehiwo Gebremichael, Kebede Embaye Gezae, Maryam Ghasemi‐Kasman, Kidu Gidey Weldegwergs, Meaza Girma Degefa, E. V. Gnedovskaya, Tekleberhan B Hagos, Arvin Haj‐Mirzaian, Arya Haj‐Mirzaian, Hamid Yimam Hassen, Simon I Hay, Mihajlo Jakovljević, Amir Kasaeian, Tesfaye Kassa, Yousef Khader, Ibrahim Khalil, Ejaz Ahmad Khan, Jagdish Khubchandani, Adnan Kısa, Kristopher J Krohn, Chanda Kulkarni, Yirga Legesse Nirayo, Mark T. Mackay, Marek Majdán, Azeem Majeed, Treh Manhertz, Man Mohan Mehndiratta, Tesfa Mekonen, Hagazi Gebre Meles, Getnet Mengistu, Shafiu Mohammed, Mohsen Naghavi, Ali H. Mokdad, Ghulam Mustafa, Seyed Sina Naghibi Irvani, Long Hoang Nguyen, Molly R Nixon, Felix Akpojene Ogbo, Andrew T Olagunju, Tinuke O Olagunju, Mayowa Owolabi, Michael Phillips, Gabriel David Pinilla-Monsalve, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Vafa Rahimi‐Movaghar, Nickolas Reinig, Perminder S. Sachdev, Hosein Safari, Saeed Safari, Saeid Safiri, Mohammad Ali Sahraian, Abdallah M Samy, Shahabeddin Sarvi, Monika Sawhney, Masood Ali Shaikh, Mehdi Sharif, Gagandeep Singh, Mari Smith, Cassandra Szoeke, Rafael Tabarés‐Seisdedos, Mohamad‐Hani Temsah, Omar Temsah, Miguel Tortajada‐Girbés, Bach Xuan Tran, Amanuel Tsegay, Irfan Ullah, Narayanaswamy Venketasubramanian, Ronny Westerman, Andrea Sylvia Winkler, Ebrahim M Yimer, Naohiro Yonemoto, Valery L. Feigin, Theo Vos, Christopher J L Murray · 发表于：The Lancet Neurology · 年份：2019 · DOI：10.1016/s1474-4422(18)30454-x · 被引用次数：1026 · 研究领域：Epilepsy research and treatment、Pharmacological Effects and Toxicity Studies、Psychosomatic Disorders and Their Treatments

BACKGROUND: Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study. METHODS: We assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016. Burden was measured as deaths, prevalence, and disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability), by age, sex, year, location, and Socio-demographic Index (SDI; a compound measure of income per capita, education, and fertility). Vital registrations and verbal autopsies provided information about deaths, and data on the prevalence and severity of epilepsy largely came from population representative surveys. All estimates were calculated with 95% uncertainty intervals (UIs). FINDINGS: In 2016, there were 45·9 million (95% UI 39·9-54·6) patients with all-active epilepsy (both idiopathic and secondary epilepsy globally; age-standardised prevalence 621·5 per 100 000 population; 540·1-737·0). Of these patients, 24·0 million (20·4-27·7) had active idiopathic epilepsy (prevalence 326·7 per 100 000 population; 278·4-378·1). Prevalence of ac...