Palladium-Catalyzed C–H Bond Monofluorination of 2-Arylbenzo[d]oxazinone Using Nitrate as Crucial Promoter

作者：Xuqin Li, Huu-Manh Vu, Feiwu Chen · 发表于：Synthesis · 年份：2019 · DOI：10.1055/s-0037-1611700 · 被引用次数：53 · 研究领域：Fluorine in Organic Chemistry、Synthesis and Biological Evaluation、Catalytic C–H Functionalization Methods

Monofluorination of 2-arylbenzo[d]oxazinones with N-fluorobenzenesulfonimide (NFSI) was achieved by palladium catalysis in moderate to good yields. Promoted by nitrate, the reaction provides an economic and environmentally friendly strategy. The synthesis of monofluorinated 2-arylbenzo[d]oxazinones has good compatibility with many common functional groups. The plausible mechanism of this monofluorination is discussed.