Noninvasive Quantification of Pressure-Volume Loops From Brachial Pressure and Cardiovascular Magnetic Resonance

作者：Felicia Seemann, Per M. Arvidsson, David Nordlund, Sascha Kopic, Marcus Carlsson, Håkan Arheden, Einar Heiberg · 发表于：Circulation Cardiovascular Imaging · 年份：2019 · DOI：10.1161/circimaging.118.008493 · 被引用次数：99 · 研究领域：Cardiovascular Function and Risk Factors、Cardiovascular Health and Disease Prevention、Cardiac Imaging and Diagnostics

BACKGROUND: Pressure-volume (PV) loops provide a wealth of information on cardiac function but are not readily available in clinical routine or in clinical trials. This study aimed to develop and validate a noninvasive method to compute individualized left ventricular PV loops. METHODS: The proposed method is based on time-varying elastance, with experimentally optimized model parameters from a training set (n=5 pigs), yielding individualized PV loops. Model inputs are left ventricular volume curves from cardiovascular magnetic resonance imaging and brachial pressure. The method was experimentally validated in a separate set (n=9 pig experiments) using invasive pressure measurements and cardiovascular magnetic resonance images and subsequently applied to human healthy controls (n=13) and patients with heart failure (n=28). RESULTS: There was a moderate-to-excellent agreement between in vivo-measured and model-calculated stroke work (intraclass correlation coefficient, 0.93; bias, -0.02±0.03 J), mechanical potential energy (intraclass correlation coefficient, 0.57; bias, -0.04±0.03 J), and ventricular efficiency (intraclass correlation coefficient, 0.84; bias, 3.5±2.1%). The model yielded lower ventricular efficiency ( P<0.0001) and contractility ( P<0.0001) in patients with heart failure compared with controls, as well as a higher potential energy ( P<0.0001) and energy per ejected volume ( P<0.0001). Furthermore, the model produced realistic values of stroke work and physiol...