Cell shape and substrate stiffness drive actin-based cell polarity

作者：Mukund Gupta, Bryant L. Doss, Leyla Kocgozlu, Meng Pan, René‐Marc Mège, Andrew Callan-Jones, Raphaël Voituriez, Benoît Ladoux · 发表于：Physical review. E · 年份：2019 · DOI：10.1103/physreve.99.012412 · 被引用次数：54 · 研究领域：Cellular Mechanics and Interactions、Biocrusts and Microbial Ecology、Force Microscopy Techniques and Applications

A general trait of living cells is their ability to exert contractile stresses on their surroundings and thus respond to substrate rigidity. At the cellular scale, this response affects cell shape, polarity, and ultimately migration. The regulation of cell shape together with rigidity sensing remains largely unknown. In this article we show that both substrate rigidity and cell shape contribute to drive actin organization and cell polarity. Increasing substrate rigidity affects bulk properties of the actin cytoskeleton by favoring long-lived actin stress fibers with increased nematic interactions, whereas cell shape imposes a local alignment of actin fibers at the cell periphery.