Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

作者：Amay J. Bandodkar, Philipp Gutruf, Jungil Choi, KunHyuck Lee, Yurina Sekine, Jonathan T. Reeder, William J. Jeang, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Roozbeh Ghaffari, Chun-Ju Su, John P. Leshock, Tyler R. Ray, Anthony Verrillo, Kyle Thomas, Vaishnavi Krishnamurthi, Seungyong Han, Jeonghyun Kim, Siddharth Krishnan, Tao Hang, John A. Rogers · 发表于：Science Advances · 年份：2019 · DOI：10.1126/sciadv.aav3294 · 被引用次数：757 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Advanced Chemical Sensor Technologies、Analytical Chemistry and Sensors

Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.