Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue

作者：Adam C. Lehnig, Revati S. Dewal, Lisa A. Baer, Kathryn M. Kitching, Vítor Rosetto Muñoz, Peter J. Arts, Devin Sindeldecker, Francis J. May, Hans P.M.M. Lauritzen, Laurie J. Goodyear, Kristin I. Stanford · 发表于：iScience · 年份：2019 · DOI：10.1016/j.isci.2018.12.033 · 被引用次数：114 · 研究领域：Adipose Tissue and Metabolism、Adipokines, Inflammation, and Metabolic Diseases、Cardiovascular Disease and Adiposity

Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, and interscapular brown adipose tissue (iBAT). Although these AT depots play important roles in metabolism, they account for only ∼50% of the AT mass in a mouse. Here, we investigated the effects of 3 weeks of exercise training on all 14 AT depots. Exercise induced depot-specific effects in genes involved in mitochondrial activity, glucose metabolism, and fatty acid uptake and oxidation in each adipose tissue (AT) depot. These data demonstrate that exercise training results in unique responses in each AT depot; identifying the depot-specific adaptations to AT in response to exercise is essential to determine how AT contributes to the overall beneficial effect of exercise.