Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis

作者：Yili Zhang, Yan Chai, Xiaojie Pan, Hao Shen, Xu Wei, Yan‐Ming Xie · 发表于：Clinical Interventions in Aging · 年份：2019 · DOI：10.2147/cia.s187588 · 被引用次数：34 · 研究领域：Bone health and osteoporosis research、Therapeutic Uses of Natural Elements、Bone Metabolism and Diseases

Purpose: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. Methods: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted using RevMan 5.3 and TSA 0.9. Results: Fifteen randomized controlled trials involving a total of 857 patients were included in the analyses. No trials reported primary outcome; however, bone mineral density (BMD) values differed significantly in subgroup 1 (TC vs no treatment; weighted mean difference [WMD] =0.05 g/cm 2 , 95% CI 0.03 to 0.07; P <0.00001; P for heterogeneity =0.22, I2 =22%) and subgroup 2 (TC vs conventional treatments; WMD =0.16 g/cm 2 , 95% CI 0.11 to 0.21; P <0.00001; P for heterogeneity =0.008, I 2 =75%). In addition, two trials compared TC with conventional treatments, which found a significant difference in bone gla protein (standardized mean difference =-1.18, 95% CI −1.66 to −0.70; P <0.00001; P for heterogeneity =0.58, I 2 =75%). The results of the BMD were confirmed by TSA. Also, TC may have a certain effect on the relief of osteoporotic pain (WMD = −2.61, 95% CI -3.51 to −1.71; WMD = −1.39, 95% CI −2.01 to −0.77). However, it did not promote the quality of life, level of serum calcium, serum phosphorus, and also had no effect on bone t...