Recent Advances in Nanozyme Research

作者：Hui Wang, Kaiwei Wan, Xinghua Shi · 发表于：Advanced Materials · 年份：2018 · DOI：10.1002/adma.201805368 · 被引用次数：981 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Advanced biosensing and bioanalysis techniques

As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational research of nanozymes on two issues over the past decade is briefly reviewed: (1) experimental development of new nanozymes mimicking different types of enzymes. This covers their structures and applications ranging from biosensing and bioimaging to therapeutics and environmental protection. (2) The catalytic mechanism proposed by experimental and theoretical study. The challenges and future directions of computational research in this field are also discussed.