Exposure to Ambient Particles Alters the Evolution of Macrophage Phenotype and Amplifies the Inducible Release of Eotaxin-1 in Allergen-Sensitized Mice

作者：Jiaxiang Zhang, Xiaoning Zeng, Ye-Shan Li, Wenxue Zhao, Zhongqi Chen, Qiang Du, Fang Zhou, Ningfei Ji, Mao Huang · 发表于：Journal of Biomedical Nanotechnology · 年份：2018 · DOI：10.1166/jbn.2019.2692 · 被引用次数：15 · 研究领域：Asthma and respiratory diseases、Air Quality and Health Impacts、Inhalation and Respiratory Drug Delivery

, no significant polarization of BMDM was found when treated with PM2.5. Together, our findings suggested that PM2.5 could exacerbate asthma by aggravating M2-polarization, highlighting for the first time that Eotaxin-1 released from M2 macrophages plays a crucial role in asthma pathogenesis.