The Prognostic Value and Regulatory Mechanisms of microRNA-145 in Various Tumors: A Systematic Review and Meta-analysis of 50 Studies

作者：Liangliang Xu, Yanfang Zhang, Jianwei Tang, Peng Wang, Lian Li, Xiaokai Yan, Xiaobo Zheng, Shengsheng Ren, Ming Zhang, Mingqing Xu · 发表于：Cancer Epidemiology Biomarkers & Prevention · 年份：2019 · DOI：10.1158/1055-9965.epi-18-0570 · 被引用次数：30 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Cancer-related molecular mechanisms research

Abstract Acting as an important tumor-related miRNA, the clinical significance and underlying mechanisms of miR-145 in various malignant tumors have been investigated by numerous studies. This study aimed to comprehensively estimate the prognostic value and systematically illustrate the regulatory mechanisms of miR-145 based on all eligible literature. Relevant studies were acquired from multiple online databases. Overall survival (OS) and progression-free survival (PFS) were used as primary endpoints. Detailed subgroup analyses were performed to decrease the heterogeneity among studies and recognize the prognostic value of miR-145. All statistical analyses were performed with RevMan software version 5.3 and STATA software version 14.1. A total of 48 articles containing 50 studies were included in the meta-analysis. For OS, the pooled results showed that low miR-145 expression in tumor tissues was significantly associated with worse OS in patients with various tumors [HR = 1.70; 95% confidence interval (CI), 1.46–1.99; P < 0.001). Subgroup analysis based on tumor type showed that the downregulation of miR-145 was associated with unfavorable OS in colorectal cancer (HR = 2.17; 95% CI, 1.52–3.08; P < 0.001), ovarian cancer (HR = 2.15; 95% CI, 1.29–3.59; P = 0.003), gastric cancer (HR = 1.78; 95% CI, 1.35–2.36; P < 0.001), glioma (HR = 1.65; 95% CI, 1.30–2.10; P < 0.001), and osteosarcoma (HR = 2.28; 95% CI, 1.50–3.47; P < 0.001). For PFS, the ...