Diabetic Human Adipose-Derived Stem Cells Accelerate Pressure Ulcer Healing by Inducing Angiogenesis and Neurogenesis

作者：Shune Xiao, Zhiyuan Liu, Yuanzhen Yao, Zai Rong Wei, Dali Wang, Chengliang Deng · 发表于：Stem Cells and Development · 年份：2019 · DOI：10.1089/scd.2018.0245 · 被引用次数：37 · 研究领域：Wound Healing and Treatments、Mesenchymal stem cell research、Pressure Ulcer Prevention and Management

Adipose-derived stem cells (ASCs) possess a well-characterized capacity to enhance cutaneous wound healing. However, many controversies exist regarding ASCs from diabetic patients (dASCs). No report exists on the administration of dASCs for the treatment of pressure ulcers. The aim of this study was to compare properties of dASCs and nondiabetic ASCs (nASCs). In addition, we studied if dASCs enhanced pressure ulcer healing in a rodent pressure ulcer model and investigated underlying mechanisms. We found similar expression of cell surface markers and characteristics in dASCs and nASCs, although dASCs exhibited decreased proliferation and osteogenic differentiation capacity and enhanced adipogenic differentiation capacity. dASCs had beneficial effects on chronic wound healing, though some aspects of their capacity were impaired. The ability of dASCs to promote nerve regeneration was not compromised. dASCs promoted pressure ulcer healing and improved healing by modulating inflammation, promoting angiogenesis and neuroregeneration, enhancing collagen deposition, and increasing re-epithelization. These data may provide a theoretical foundation for further clinical administration of ASCs for chronic wound healing in patients with diabetes.