Phosphatase-like Activity of Porous Nanorods of CeO 2 for the Highly Stabilized Dephosphorylation under Interferences

作者：Tianzhu Yao, Zhimin Tian, Yinqing Zhang, Yongquan Qu · 发表于：ACS Applied Materials & Interfaces · 年份：2018 · DOI：10.1021/acsami.8b17086 · 被引用次数：121 · 研究领域：Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques、Nanocluster Synthesis and Applications

Nanoceria with phosphatase-like behavior shows its great potential for many important biological applications through a catalytic dephosphorylation process. Herein, we synthesize a series of porous nanorods of ceria (PN-CeO 2 ) with the controllable surface Ce 3+ fractions modulated by thermal annealing, understanding the correlations between their surface properties and reactivity for the dephosphorylation of p -nitrophenyl phosphate ( p -NPP) and investigating their catalytic performance under various interferences. Our results suggest that PN-CeO 2 with abundant surface defects deliver higher catalytic activity to break down p -NPP. Most importantly, PN-CeO 2 exhibited a better adaptability over a wide pH range and preserved the catalytic activity over a wide temperature range from 20 to 80 °C, if compared with natural enzymes. Moreover, PN-CeO 2 delivered the high catalytic stability against various interference ions. Their great prospects for practical applications were further demonstrated by dephosphorylation of DNA.