A new indole-type alkaloid from the roots of Clematis florida var. plena

作者：Kai‐Hui Sun, Xinhua Ma, Xianming Zeng, Zhong-Yue Lin, Yu-Mei Cai, Haitao Zhang, Xiaoyan Lin, Shi-Biao Feng, Tian‐Hua Zhong, Yonghong Zhang · 发表于：Natural Product Research · 年份：2018 · DOI：10.1080/14786419.2018.1510396 · 被引用次数：12 · 研究领域：Natural product bioactivities and synthesis、Phytochemistry and Biological Activities、Bioactive Compounds and Antitumor Agents

One new indole-type alkaloid, α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranosyl 6-methoxy-3-indolecarbonate (1), together with three known alkaloids (2–4), one aromatic acid (5) and five known saponins (6–10), was isolated from the roots of Clematis florida var. plena. Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In in vivo anti-inflammatory activity, n-butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds 8 and 9 obtained from the n-butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg.