Metal‐Free Access to ( E/Z )‐α‐Fluorovinyl Phosphorus Compounds from gem ‐Difluorostyrenes

作者：Yingyuan Peng, Xiaofei Zhang, Xueyu Qi, Qian He, Bin Zhang, Jian Hao, Chunhao Yang · 发表于：European Journal of Organic Chemistry · 年份：2018 · DOI：10.1002/ejoc.201801602 · 被引用次数：18 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions

A facile and efficient method for the synthesis of ( E/Z )‐α‐fluorovinyl phosphorus compounds from gem ‐difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1‐fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers ( E/Z type) of the target compounds could be easily separated and purified by column chromatography.