Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment

作者：Chunyu Xia, Sheng Yin, Shanshan Xu, Guang‐Yao Ran, Miao Deng, Ling Mei, Xian Tang, Jingdong Rao, Man Li, Zhirong Zhang, Qin He · 发表于：Theranostics · 年份：2018 · DOI：10.7150/thno.29026 · 被引用次数：71 · 研究领域：Nanoplatforms for cancer theranostics、Immunotherapy and Immune Responses、Cancer Immunotherapy and Biomarkers

The immune activation and multiple anti-metastatic effects of LMWH/PPD/CpG establish a novel therapeutic strategy for melanoma. This anti-metastatic nanoplatform could be broadly applied for the co-delivery of other nucleic acids and chemotherapeutic drugs to treat highly aggressive tumors.