Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer

作者：Lei‐Yun Wang, Jiajia Cui, Junyan Liu, Ao-Xiang Guo, Zhenyu Zhao, Yingzi Liu, Ji-Chu Wu, Min Li, Chengping Hu, Yang Gao, Hong‐Hao Zhou, Ji‐Ye Yin · 发表于：Scientific Data · 年份：2018 · DOI：10.1038/sdata.2018.284 · 被引用次数：10 · 研究领域：Lung Cancer Treatments and Mutations、Bioinformatics and Genomic Networks、Gene expression and cancer classification

Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step.