How Glucocorticoids Affect the Neutrophil Life

作者：Simona Ronchetti, Erika Ricci, Graziella Migliorati, Marco Gentili, Carlo Riccardi · 发表于：International Journal of Molecular Sciences · 年份：2018 · DOI：10.3390/ijms19124090 · 被引用次数：254 · 研究领域：Immune Response and Inflammation、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Inflammasome and immune disorders

Glucocorticoids are hormones that regulate several functions in living organisms and synthetic glucocorticoids are the most powerful anti-inflammatory pharmacological tool that is currently available. Although glucocorticoids have an immunosuppressive effect on immune cells, they exert multiple and sometimes contradictory effects on neutrophils. From being extremely sensitive to the anti-inflammatory effects of glucocorticoids to resisting glucocorticoid-induced apoptosis, neutrophils are proving to be more complex than they were earlier thought to be. The aim of this review is to explain these complex pathways by which neutrophils respond to endogenous or to exogenous glucocorticoids, both under physiological and pathological conditions.