Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

作者：Zhongqing Chen, Huang Ling-sha, Bo Zhu · 发表于：Disease Markers · 年份：2018 · DOI：10.1155/2018/9845123 · 被引用次数：95 · 研究领域：Lung Cancer Diagnosis and Treatment、Lung Cancer Treatments and Mutations、Head and Neck Cancer Studies

Background . The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported. Methods. TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), and 103 cases of benign chest disease (BCD) were analyzed before treatment. Results . By Kendall’s tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC ( r = 0.235 , p < 0.05 ; r = 0.298 , p < 0.05 ; r = 0.254 , p < 0.05 ; r = 0.063 , p < 0.05 ; r = 0.080 , p < 0.05 ; r = 0.268 , p < 0.05 ; and r = 0.080 , p < 0.05 ). CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with N stage of LAC ( r = 0.356 , p < 0.05 ; r = 0.415 , p < 0.05 ; r = 0.340 , p < 0.05 ; r = 0.117 , p < 0.05 ; r = 0.175 , p < 0.05 ; and r = 0.351 , p < 0.05 ). CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with M stage of LAC ( r = 0.365 , p < 0.05 ; r = 0.353 , p < 0.05 ; r = 0.293 , p < 0.05 ; r = 0.135 , p < 0.05 ; r = 0.169 , p < 0.05 ; and r = 0.312 , p < 0.05 ). CA125, CYFRA21-1, and SCC-Ag were correlated with T stage of LSCC ( r = 0.202 , p < ...