The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy

作者：Yazhuo Huang, Sijie Fang, Dan Li, Huifang Zhou, Bin Li, Xianqun Fan · 发表于：Eye · 年份：2018 · DOI：10.1038/s41433-018-0279-9 · 被引用次数：114 · 研究领域：Ophthalmology and Eye Disorders、Ocular Diseases and Behçet’s Syndrome、IgG4-Related and Inflammatory Diseases

Thyroid-associated ophthalmoapthy (TAO) is the most common orbital disease. As an autoimmune disorder, it is caused by self-reactive lymphocytes that escape immune tolerance, but the mechanism is not fully understood. The basic process of TAO is the infiltration of immune cells in orbital tissues, the activation of orbital fibroblasts (OFs), and the proliferation and differentiation of OFs and lymphocytes. Activated OFs secrete inflammatory regulators, growth factors, and chemokines, thereby maintaining and amplifying the immune responses. The interactions between OFs and lymphocytes lead to the expansion and the remodeling of the orbital tissues, presenting the clinical manifestations of TAO. This review will focus on the role of T cell subsets (Type 1, Type 2, Type 17 helper T cells, and regulatory T cells) in the pathogenesis of TAO. However, we still need further studies to unravel the pathogenesis, to confirm current hypotheses, and to provide novel ideas for appropriate clinical treatment of TAO.