Clinical features of 2041 human brucellosis cases in China

作者：Yujing Shi, Hui Gao, Γεώργιος Παππάς, Qiulan Chen, Mei Li, Jun Xu, Shengjie Lai, Qiaohong Liao, Wenwen Yang, Zhongtao Yi, Zulaguli Rouzi, Hongjie Yu · 发表于：PLoS ONE · 年份：2018 · DOI：10.1371/journal.pone.0205500 · 被引用次数：70 · 研究领域：Brucella: diagnosis, epidemiology, treatment、Zoonotic diseases and public health、Burkholderia infections and melioidosis

BACKGROUND: Human brucellosis has become a major public health problem in China. However, the available clinical data on brucellosis cases are limited. METHODS: We retrospectively reviewed medical charts of 2041 patients with confirmed human brucellosis and prospectively recorded their outcomes by telephone interview. These patients were admitted to the Sixth People's Hospital of the Xinjiang Uygur Autonomous region between 1st January and 31st December 2014. Data on these patients were collected from hospital medical records. RESULTS: Many patients presented with fatigue (67%), fever (64%), arthralgia (63%) and sweating (54%). High erythrocyte sedimentation rate (ESR) (69%), high C-reactive protein (CRP) (39%), high alanine aminotransferase (ALT) (33%) and high aspartate aminotransferase (AST) (20%) were the most common laboratory findings, especially in acute patients. There was evidence of focal involvement in 90% of patients. A total of 61.5% of brucellosis patients recovered. Multivariate logistic regression analyses suggested that the risk factors key to unfavorable prognosis were: age≥45 years (OR = 1.75, 95% CI 1.36-2.24), back pain (OR = 1.50, 95% CI 1.16-1.94) and joint tenderness (OR = 1.73, 95% CI 1.13-2.65). The increasing duration of the illness increased the risk of poor prognosis. CONCLUSION: Patients with brucellosis showed different characteristics in different clinical stages. In China, the chronicity rate of human brucellosis is high. The risk of poor prog...