Response rates in patients with schizophrenia and positive symptoms receiving cognitive behavioural therapy: a systematic review and single-group meta-analysis

作者：Irene Bighelli, Maximilian Huhn, Johannes Schneider‐Thoma, Marc Krause, Cornelia Reitmeir, Sofia Wallis, Felicitas Schwermann, Gabi Pitschel‐Walz, Corrado Barbui, Toshi A. Furukawa, Stefan Leucht · 发表于：BMC Psychiatry · 年份：2018 · DOI：10.1186/s12888-018-1964-8 · 被引用次数：52 · 研究领域：Schizophrenia research and treatment、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Healthcare Decision-Making and Restraints

BACKGROUND: Cognitive behavioural therapy has been used for schizophrenia, but to which extent it is effective is still controversial. Results of existing meta-analyses are of difficult interpretation, because they mainly present effect sizes in the form of standardized mean differences between intervention and control groups based on rating scales, which are of unclear clinical meaning. No meta-analysis has considered the number of patients responding to treatment yet. Based on this ground, we present the first meta-analysis examining the response rates of patients with schizophrenia and positive symptoms to cognitive behavioural therapy. METHODS: We searched multiple databases for randomized controlled trials on psychological interventions of schizophrenia including patients with positive symptoms, and included for this analysis the studies on cognitive behavioural therapy (last search: January 2018). We applied a validated imputation method to calculate the number of responders from rating scales for the outcomes overall symptoms and positive symptoms, based on two criteria, at least 20% and at least 50% reduction from baseline on PANSS or BPRS total scores. Data were pooled in a single-group summary meta-analysis using R software. Additionally, several potential moderators of response to cognitive behavioural therapy were examined by subgroup and meta-regression analyses. The protocol has been registered in PROSPERO (CRD42017067795). RESULTS: We included 33 studies with a...