Updates in adjuvant systemic therapy for melanoma

作者：Minyoung Kwak, Norma E. Farrow, April K.S. Salama, Paul J. Mosca, Brent Allen Hanks, Craig Lee Slingluff, Georgia Marie Beasley · 发表于：Journal of Surgical Oncology · 年份：2018 · DOI：10.1002/jso.25298 · 被引用次数：42 · 研究领域：Immunotherapy and Immune Responses、Cutaneous Melanoma Detection and Management、CAR-T cell therapy research

There has been a rapid increase in adjuvant therapies approved for treatment following surgical resection of stages III/IV melanoma. We review current indications for adjuvant therapy, which currently includes a heterogenous group of stages III and IV patients with melanoma. We describe several pivotal clinical trials of systemic immune therapies, targeted immune therapies, and adjuvant vaccine strategies. Finally, we discuss the evidence for selecting the most appropriate treatment regimen(s) for the individual patient.