Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals

作者：Yousef Hannawi, Lisa R. Yanek, Brian G. Kral, Dhananjay Vaidya, Lewis C. Becker, Diane M. Becker, Paul Nyquist · 发表于：American Journal of Neuroradiology · 年份：2018 · DOI：10.3174/ajnr.a5871 · 被引用次数：41 · 研究领域：Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications、Dementia and Cognitive Impairment Research

BACKGROUND AND PURPOSE: Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease. MATERIALS AND METHODS: This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis. RESULTS: Included were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with reg...