Macrophage functions in wound healing

作者：Małgorzata Kloc, Rafik Mark Ghobrial, Jarek Wosik, Aneta Lewicka, Sławomir Lewicki, Jacek Z. Kubiak · 发表于：Journal of Tissue Engineering and Regenerative Medicine · 年份：2018 · DOI：10.1002/term.2772 · 被引用次数：126 · 研究领域：Wound Healing and Treatments、Immune cells in cancer、Signaling Pathways in Disease

Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.