Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells

作者：Sai Priya Anand, Jérémie Prévost, Sophie Baril, Jonathan Richard, Halima Medjahed, Jean-Philippe Chapleau, William D. Tolbert, Sharon Kirk, Amos B. Smith, Bruce D. Wines, Stephen J. Kent, P. Mark Hogarth, Matthew S. Parsons, Marzena Pazgier, Andrés Finzi · 发表于：Journal of Virology · 年份：2018 · DOI：10.1128/jvi.01823-18 · 被引用次数：69 · 研究领域：Monoclonal and Polyclonal Antibodies Research、HIV Research and Treatment、Chronic Lymphocytic Leukemia Research

The “open” CD4-bound conformation of HIV-1 envelope glycoproteins is the primary target of antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies present in HIV-positive (HIV + ) sera, such as anti-coreceptor binding site and anti-cluster A antibodies. Here we report that the binding of these two families of antibodies is required to engage FcγRIIIa and mediate ADCC.