Analysis of Brain Donors’ Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China

作者：Hanlin Zhang, Kang Chen, Naili Wang, Di Zhang, Qian Yang, Qing Zhang, Pan Liu, Mengyao Wan, Changlin Gong, Xinyu Hong, Wenying Qiu, Xiaojing Qian, Yongmei Chen, Chao Ma · 发表于：Journal of Alzheimer s Disease · 年份：2018 · DOI：10.3233/jad-180779 · 被引用次数：21 · 研究领域：Epilepsy research and treatment、Neonatal and fetal brain pathology、Anesthesia and Neurotoxicity Research

The Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS/PUMC) Human Brain Bank was established in December 2012 and had accomplished 197 brain donations by November 2017. The brain bank was based on a large-scale willed body donation program in CAMS/PUMC starting from 1999. Demographic and medical characteristic analysis of brain donors was conducted to facilitate the construction of the brain bank. The average postmortem delay of brain donors was 17.7 h and 77.7% of these donors died less than 15 km away from the brain bank. Donors were predominantly with higher-level education (p < 0.001) and at an older age when registration (p < 0.001) and donation (p < 0.001) occurred. Our results elucidated the characteristics of donors in the CAMS/PUMC Human Brain Bank, which may provide useful information to target potential donors and improve the quality and quantity of brain specimens. The current study may pave the way for the construction of a nationwide network of standardized human brain banks in China.