Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

作者：JoAnn E. Manson, Nancy R. Cook, I‐Min Lee, William G. Christen, Shari S. Bassuk, Samia Mora, Heike Luttmann Gibson, Christine M. Albert, David Gordon, Trisha Copeland, Denise D’Agostino, Georgina Friedenberg, Claire Ridge, Vadim Y. Bubes, Edward L. Giovannucci, Walter Churchill Willett, Julie E. Buring · 发表于：New England Journal of Medicine · 年份：2018 · DOI：10.1056/nejmoa1811403 · 被引用次数：989 · 研究领域：Fatty Acid Research and Health、Antioxidant Activity and Oxidative Stress、Metabolomics and Mass Spectrometry Studies

BACKGROUND: Higher intake of marine n-3 (also called omega-3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether supplementation with n-3 fatty acids has such effects in general populations at usual risk for these end points is unclear. METHODS: (at a dose of 2000 IU per day) and marine n-3 fatty acids (at a dose of 1 g per day) in the primary prevention of cardiovascular disease and cancer among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were major cardiovascular events (a composite of myocardial infarction, stroke, or death from cardiovascular causes) and invasive cancer of any type. Secondary end points included individual components of the composite cardiovascular end point, the composite end point plus coronary revascularization (expanded composite of cardiovascular events), site-specific cancers, and death from cancer. Safety was also assessed. This article reports the results of the comparison of n-3 fatty acids with placebo. RESULTS: A total of 25,871 participants, including 5106 black participants, underwent randomization. During a median follow-up of 5.3 years, a major cardiovascular event occurred in 386 participants in the n-3 group and in 419 in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.80 to 1.06; P=0.24). Invasive cancer was diagnosed in 820 participants in the n-3 group and in 797 in the place...