A next generation probiotic, Akkermansia muciniphila

作者：Qixiao Zhai, Saisai Feng, Arjan Narbad, Wei Chen · 发表于：Critical Reviews in Food Science and Nutrition · 年份：2018 · DOI：10.1080/10408398.2018.1517725 · 被引用次数：448 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Infant Nutrition and Health

Akkermansia muciniphila, a symbiotic bacterium of the mucus layer, can utilize mucin as its sole carbon, nitrogen, and energy source. As an abundant resident in the intestinal tract of humans and animals, the probiotic effects of A. muciniphila including metabolic modulation, immune regulation and gut health protection, have been widely investigated. Various diseases such as metabolic syndromes and auto-immnue diseases have been reported to be associated with the disturbance of the abundance of A. muciniphila. In this review, we describe the biological characterization of A. muciniphia, the factors that influence its colonization of the intestinal tract; and discuss the current state of our knowledge on its role in host health and disease.