iDog: an integrated resource for domestic dogs and wild canids

作者：Bixia Tang, Qing Zhou, Lili Dong, Wulue Li, Xiangquan Zhang, Lan Li, Shuang Zhai, Jingfa Xiao, Zhang Zhang, Yīmíng Bào, Ya‐Ping Zhang, Guodong Wang, Wenming Zhao · 发表于：Nucleic Acids Research · 年份：2018 · DOI：10.1093/nar/gky1041 · 被引用次数：45 · 研究领域：Human-Animal Interaction Studies、Genomics and Phylogenetic Studies、Zoonotic diseases and public health

The domestic dog (Canis lupus familiaris) is indisputably one of man's best friends. It is also a fundamental model for many heritable human diseases. Here, we present iDog (http://bigd.big.ac.cn/idog), the first integrated resource dedicated to domestic dogs and wild canids. It incorporates a variety of omics data, including genome sequences assemblies for dhole and wolf, genomic variations extracted from hundreds of dog/wolf whole genomes, phenotype/disease traits curated from dog research communities and public resources, gene expression profiles derived from published RNA-Seq data, gene ontology for functional annotation, homolog gene information for multiple organisms and disease-related literature. Additionally, iDog integrates sequence alignment tools for data analyses and a genome browser for data visualization. iDog will not only benefit the global dog research community, but also provide access to a user-friendly consolidation of dog information to a large number of dog enthusiasts.