New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

作者：Wei Yan, Lingling Cao, Yangyang Zhang, Ran Zhao, Shuangshuang Zhao, Babar Khan, Yonghao Ye · 发表于：Molecules · 年份：2018 · DOI：10.3390/molecules23112873 · 被引用次数：42 · 研究领域：Plant Pathogens and Fungal Diseases、Fungal Biology and Applications、Mycotoxins in Agriculture and Food

Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3–5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%).