A Study of the Correlation of Perfusion Parameters in High‐Resolution GRASP MRI With Microvascular Density in Lung Cancer

作者：Lihua Chen, Xianchun Zeng, You-Li Wu, Xiaochu Yan, Xuequan Huang, Hui Chen, Jiuquan Zhang, Jian Wang, Li Feng · 发表于：Journal of Magnetic Resonance Imaging · 年份：2018 · DOI：10.1002/jmri.26340 · 被引用次数：14 · 研究领域：MRI in cancer diagnosis、Radiomics and Machine Learning in Medical Imaging、Angiogenesis and VEGF in Cancer

Background The histological count of microvascular density (MVD) is the current clinical standard for assessing tumor angiogenesis. Although it is hypothesized that perfusion MRI can be a noninvasive alternative to MVD, there have been few studies to validate their correlations, particularly in lung cancer. Purpose To investigate the correlation between MVD and perfusion parameters obtained from high‐resolution GRASP (Golden‐angle RAdial Sparse Parallel) dynamic contrast‐enhanced (DCE)‐MRI in a cohort of lung cancer patients, and to validate that GRASP MRI can serve as a free‐breathing, noninvasive imaging approach for studying tumor angiogenesis. Study Type Prospective. Population Twenty‐five lung cancer patients (16 male, 9 female, mean age = 57.3 ± 11.7 years). Field Strength/Sequence 3T MRI; a prototype golden‐angle stack‐of‐stars sequence. Assessment Contrast‐enhanced MR data were acquired during free breathing and were reconstructed using GRASP with a temporal resolution of ∼3 sec/phase. For all data, perfusion analysis was performed using a standard Tofts model to generate the volume transfer coefficient (K trans ) and the interstitial volume (V e ). The MVD of corresponding tumor specimens, obtained from Computed Tomography‐guided biopsies, were counted with CD34 staining. Statistical Tests Pearson correlation analysis; one‐way analysis of variance analysis; least significant difference‐t method of multiple comparisons. Results The correlation coefficient was 0.983 an...