Phosphodiesterase EdpX1 Promotes Xanthomonas oryzae pv. oryzae Virulence, Exopolysaccharide Production, and Biofilm Formation

作者：Dingrong Xue, Fang Tian, Fenghuan Yang, Huamin Chen, Xiaochen Yuan, Ching‐Hong Yang, Yihua Chen, Qi Wang, Chenyang He · 发表于：Applied and Environmental Microbiology · 年份：2018 · DOI：10.1128/aem.01717-18 · 被引用次数：21 · 研究领域：Plant Pathogenic Bacteria Studies、Vibrio bacteria research studies、Bacterial biofilms and quorum sensing

Bacteria utilize c-di-GMP as a second messenger to regulate various biological functions. The synthesis and degradation of c-di-GMP are catalyzed by GGDEF domains and an EAL or HD-GYP domain, respectively. Multiple genes encoding these domains are often found in one bacterial strain. For example, in the genome of X. oryzae pv. oryzae PXO99 A , 26 genes encoding proteins containing these domains were identified. Therefore, to fully appreciate the complexity and specificity of c-di-GMP signaling in X. oryzae pv. oryzae, the enzymatic activities and regulatory functions of each GGDEF, EAL, and HD-GYP domain protein need to be elucidated. In this study, we showed that the EAL domain protein EdpX1 is a major PDE to regulate diverse virulence phenotypes through the c-di-GMP signaling pathway.