Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma

作者：Yingchun Zhu, Yunfeng Mi, Zheyang Wang, Xuewen Jia, Zhanping Jin · 发表于：Oncology Letters · 年份：2018 · DOI：10.3892/ol.2018.9615 · 被引用次数：10 · 研究领域：Beetle Biology and Toxicology Studies、Coleoptera Taxonomy and Distribution

Osteosarcoma is the most frequent malignant bone tumor in children and adolescents. Norcantharidin (NCTD) is a purified component from blister beetles and has been identified to exert antitumor effects in a variety of cancer types. However, the antitumor effect of NCTD in osteosarcoma remains to be elucidated. In the current study, it was first demonstrated that NCTD inhibited proliferation and induced G2/M-phase arrest and cell apoptosis in human osteosarcoma cells. Furthermore, NCTD significantly decreased the phosphorylation of Akt and the mammalian target of rapamycin in human osteosarcoma cells. These results suggest that NCTD is a promising candidate for the treatment of osteosarcoma patients in the future.