Direct Conversion of Benzyl Ethers into Aryl Nitriles

作者：Yunlai Ren, Jianji Wang, Xinzhe Tian, Fangping Ren, Xinqiang Cheng, Shuang Zhao · 发表于：Synlett · 年份：2018 · DOI：10.1055/s-0037-1611062 · 被引用次数：27 · 研究领域：Chemical Synthesis and Reactions、Oxidative Organic Chemistry Reactions、Innovative Microfluidic and Catalytic Techniques Innovation

A direct method was developed for the conversion of benzyl ethers into aryl nitriles by using NH4OAc as the nitrogen source and ­oxygen as the terminal oxidant with catalysis by TEMPO/HNO3; the method is valuable for both the synthesis of aromatic nitriles and for the deprotection of ether-protected hydroxy groups to form nitrile groups in multistep organic syntheses.