Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults

作者：Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li · 发表于：Clinical Interventions in Aging · 年份：2018 · DOI：10.2147/cia.s180934 · 被引用次数：78 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Adipokines, Inflammation, and Metabolic Diseases

Purpose: Frailty is associated with adverse health outcomes. Its biological markers are essential to enhance diagnostic ease and would contribute to surveillance of the condition. Considering the involvement of pro-inflammatory and nutritional states in frailty, we aimed to investigate whether inflammatory mediators and adipokines are associated with frailty and their relationship with physical function. Patients and methods: We recruited 130 older adults (90 nonfrail participants and 40 frail participants, mean age: 72.80±8.61 years) who underwent a comprehensive medical history and frailty assessment. The biochemical indicators (eg, blood urea nitrogen [BUN], high-density lipoprotein [HDL], and hemoglobin [HGB]), insulin pathway (glucose, insulin, and insulin-like growth factor 1 [IGF-1]), circulating inflammatory biomarkers (IL-6, tumor necrosis factor receptor 1, and C-reactive protein), and adipokines (adiponectin, vaspin, and leptin) were compared between the two groups. We further analyzed their correlation with physical function. Results: Frail older adults showed higher levels of BUN, IL-6, adiponectin, vaspin, and glucose and lower levels of IGF-1, HDL, and HGB compared with nonfrail participants. Serum IL-6 levels were negatively correlated with both grip strength ( P =0.03) and gait speed ( P =0.04). Levels of circulating adiponectin and leptin were adversely correlated with grip strength ( P =0.01) and gait speed ( P =0.03), respectively. After adjustment for age...