Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

作者：Thomas Sonnweber, Alex Pizzini, Manfred Nairz, Günter Weiß, Ivan Tancevski · 发表于：International Journal of Molecular Sciences · 年份：2018 · DOI：10.3390/ijms19113285 · 被引用次数：448 · 研究领域：Eicosanoids and Hypertension Pharmacology、Fatty Acid Research and Health、Cholesterol and Lipid Metabolism

Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.