Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

作者：Hao Chi, Hui-Yun Chang, Tzu‐Kang Sang · 发表于：International Journal of Molecular Sciences · 年份：2018 · DOI：10.3390/ijms19103082 · 被引用次数：416 · 研究领域：Alzheimer's disease research and treatments、Parkinson's Disease Mechanisms and Treatments、Amyotrophic Lateral Sclerosis Research

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.