Effects of trimester-specific exposure to vanadium on ultrasound measures of fetal growth and birth size: a longitudinal prospective prenatal cohort study

作者：Jie Hu, Peng Yang, Tongzhang Zheng, Bin Zhang, Wenyu Liu, Chuansha Wu, Minmin Jiang, Joseph M. Braun, Simin Liu, Stephen L. Buka, Aifen Zhou, John Pierce Wise, Yiming Zhang, Yangqian Jiang, Chen Hu, Xiaomei Chen, Zheng Huang, Dan Zheng, Kunchong Shi, Xichi Zhang, Ashley Truong, Zhengmin Qian, Wei Xia, Yuanyuan Li, Shunqing Xu · 发表于：The Lancet Planetary Health · 年份：2018 · DOI：10.1016/s2542-5196(18)30210-9 · 被引用次数：56 · 研究领域：Vanadium and Halogenation Chemistry、Electrochemical Analysis and Applications、Trace Elements in Health

Background Identification of windows of heightened vulnerability to environmental factors has substantial public health implications. Prenatal exposure to vanadium has been linked to adverse birth outcomes; however, critical windows for such exposure during fetal growth remain unknown. We aimed to assess trimester-specific associations of vanadium exposure with ultrasound measures of fetal growth and birth size in a Chinese longitudinal cohort. Methods The present study was embedded in our ongoing prospective prenatal cohort study at the Wuhan Women and Children Medical Care Center (Wuhan, Hubei, China). Pregnant women were eligible for inclusion if they provided signed informed consent and were less than 16 weeks pregnant with a single gestation, and agreed to take in-person interviews, undergo ultrasound examinations, and provide blood and urine samples. We collected urine samples and measured urinary vanadium concentrations using inductively coupled plasma mass spectrometry. We calculated SD scores for ultrasound-measured biparietal diameter, head circumference, occipitofrontal diameter, abdominal circumference, femur length, and estimated fetal weight at 16, 24, and 31 weeks of gestation. We applied linear regressions with generalised estimating equations to estimate associations of urinary vanadium concentrations in each trimester with ultrasound-measured fetal growth parameters or neonatal size at birth. Findings As of Oct 12, 2016, we recruited 3075 women who were non-...