The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

作者：Swetha E. Murthy, Meaghan Loud, I. Daou, Kara L. Marshall, Frederick Schwaller, Johannes Kühnemund, Allain Francisco, William T. Keenan, Adrienne E. Dubin, Gary R. Lewin, Ardem Patapoutian · 发表于：Science Translational Medicine · 年份：2018 · DOI：10.1126/scitranslmed.aat9897 · 被引用次数：407 · 研究领域：Erythrocyte Function and Pathophysiology、Ion channel regulation and function、Ion Channels and Receptors

in caudal sensory neurons had impaired nocifensive responses to mechanical stimuli. Consistently, ex vivo recordings in skin-nerve preparations from these mice showed diminished Aδ-nociceptor and C-fiber firing in response to mechanical stimulation. Punctate and dynamic allodynia in response to capsaicin-induced inflammation and spared nerve injury was absent in Piezo2-deficient mice. These results indicate that Piezo2 mediates inflammation- and nerve injury-induced sensitized mechanical pain, and suggest that targeting PIEZO2 might be an effective strategy for treating mechanical allodynia.