A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population

作者：Na Luo, Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, not Qingdao University of Science and Technology, please correct the current affiliation. Thank you, Jiayu Chen, Fuquan Zhang, Lin Tian, Dongdong Lin, Ming Song, Vince D. Calhoun, Yue Cui, Victor M. Vergara, Fanfan Zheng, Jingyu Liu, Zhenyi Yang, Nianming Zuo, Lingzhong Fan, Kaibin Xu, Shengfeng Liu, Jian Li, Yong Xu, Sha Liu, Luxian Lv, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lü, Ping Wan, Huaning Wang, Huiling Wang, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang · 发表于：EBioMedicine · 年份：2018 · DOI：10.1016/j.ebiom.2018.10.009 · 被引用次数：53 · 研究领域：Functional Brain Connectivity Studies、Schizophrenia research and treatment、Genetic Associations and Epidemiology

BACKGROUND: In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset. METHODS: Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-susceptible single nucleotide polymorphisms (SNP) from 905 Chinese subjects were jointly analyzed, to investigate the multimodal association. Based on the identified imaging-genetic pattern, correlations with cognition and mediation analysis were then conducted to reveal the potential mediation pathways. FINDINGS: One linked imaging-genetic pattern was identified to be group discriminative, which was also associated with working memory performance. Particularly, GM reduction in thalamus, putamen and bilateral temporal gyrus in schizophrenia was associated with fALFF decrease in medial prefrontal cortex, both were also associated with genetic factors enriched in neuron development, synapse organization and axon pathways, highlighting genes including CSMD1, CNTNAP2, DCC, GABBR2 etc. This linked pattern was also replicated in an independent cohort (166 subjects), which although showed certain age and clinical differences with the discovery cohort. A further mediation analysis suggested that GM alt...