Lnc RNA net: a comprehensive Sus scrofa lnc RNA database

作者：Guoming Liang, Yuxin Yang, Haibing Li, Heguo Yu, X. Li, Zhonglin Tang, Kun Li · 发表于：Animal Genetics · 年份：2018 · DOI：10.1111/age.12720 · 被引用次数：18 · 研究领域：Cancer-related molecular mechanisms research、Plant and Fungal Interactions Research、RNA Research and Splicing

Long noncoding RNAs (lncRNAs) constitute a large class of functional non-coding RNAs that play important roles in many biological processes. Thousands of lncRNAs have been identified in mammals. Pig is an important farm animal and biomedical model. It is essential to create a Sus scrofa lncRNA database to enable further study of the function and evolution of lncRNAs. In this study, we built a systematic S. scrofa lncRNA database named lncRNAnet that contains 53 468 S. scrofa lncRNAs with their sequence characteristics, genomic locations, conservation, overlapping SNPs and QTLs, and transcript abundance across nine tissues in pigs. We also integrated 212 922 human and mouse lncRNAs sequences into lncRNAnet. This database will provide for a systematic S. scrofa lncRNA classification and help investigators browse, search for and analyze lncRNAs as well as do blast searches among human, mouse and pig lncRNAs. Thus, lncRNAnet should improve the understanding of the biological functions of lncRNA. The database is freely accessible at http://lnc.rnanet.org/.