Characterization and osteogenic evaluation of mesoporous magnesium–calcium silicate/polycaprolactone/polybutylene succinate composite scaffolds fabricated by rapid prototyping

作者：Yun Gyeong Kang, Jie Wei, Ji Eun Kim, Yan Ru Wu, Eun Jin Lee, Jiacan Su, Jung‐Woog Shin · 发表于：RSC Advances · 年份：2018 · DOI：10.1039/c8ra06281a · 被引用次数：15 · 研究领域：Bone Tissue Engineering Materials、Additive Manufacturing and 3D Printing Technologies、biodegradable polymer synthesis and properties

degradability, biocompatibility, and bioactivity in simulated body fluid, while its mechanical strength is reduced. Moreover, the results of the cytotoxicity tests specified in ISO 10993-12 and ISO 10993-5 clearly indicate that the m_MCS/PCL scaffold is not toxic to cells. In addition, we obtained significant increases in initial cell attachment and improvements to the osteogenic MSC differentiation by replacing the m_MCS/PCL scaffold with the m_MCS/PCL/PBSu scaffold. Our results indicate that the m_MCS/PCL/PBSu scaffold achieves enhanced bioactivity, degradability, cytocompatibility, and osteogenesis. As such, this scaffold is a potentially promising candidate for use in stem cell-based bone tissue engineering.