CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

作者：Lauren E. Holz, Julia E. Prier, David J. Freestone, Thiago Maass Steiner, Kieran English, Darryl N. Johnson, Vanessa Mollard, Anton J. Cozijnsen, Gayle M. Davey, Dale Ian Godfrey, Katsuyuki Yui, Laura K. Mackay, Mireille Hanna Lahoud, Irina Caminschi, Geoffrey Ian McFadden, Patrick Bertolino, Daniel Fernandez‐Ruiz, William R. Heath · 发表于：Cell Reports · 年份：2018 · DOI：10.1016/j.celrep.2018.08.094 · 被引用次数：106 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm cell development, we examined various conditions for their formation. Although liver Trm cells were found in naive mice, their presence was dictated by antigen specificity and required IL-15. Liver Trm cells also formed after adoptive transfer of in vitro -activated but not naive CD8 + T cells, indicating that activation was essential but that antigen presentation within the liver was not obligatory. These Trm cells patrolled the liver sinusoids with a half-life of 36 days and occupied a large niche that could be added to sequentially without effect on subsequent Trm cell cohorts. Together, our findings indicate that liver Trm cells form as a normal consequence of CD8 + T cell activation during essentially any infection but that inflammatory and antigenic signals preferentially tailor their development.