Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21st Newborn Case-Control Study protocol

作者：Stephen Kennedy, César G. Victora, Rachel Craik, Stephen Ash, Fernando C. Barros, Hellen C. Barsosio, James A. Berkley, Maria Carvalho, Michelle Fernandes, Leila Cheikh Ismail, Ann Lambert, Cecilia M. Lindgren, Rose McGready, Shama Munim, Christoffer Nellåker, J. Alison Noble, Shane A. Norris, François Nosten, Eric O. Ohuma, Aris T. Papageorghiou, Alan Stein, William Stones, Chrystelle O.O. Tshivuila-Matala, Eleonora Staines Urias, Manu Vatish, Katharina Wulff, Ghulam Zainab, Krina T. Zondervan, Ricardo Uauy, Zulfiqar A Bhutta, José R. Villar · 发表于：Gates Open Research · 年份：2019 · DOI：10.12688/gatesopenres.12869.2 · 被引用次数：21 · 研究领域：Neonatal Respiratory Health Research、Birth, Development, and Health、Pregnancy and preeclampsia studies

Background: INTERBIO-21 st is Phase II of the INTERGROWTH-21 st Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. Methods: In the INTERBIO-21 st Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sit...