Association of body mass index and age with incident diabetes in Chinese adults: a population-based cohort study

作者：Ying Chen, Xiaoping Zhang, Jie Yuan, Bo Cai, Xiaoli Wang, Xiaoli Wu, Yue-Hua Zhang, Xiaoyi Zhang, Tong Yin, Xiaohui Zhu, Yunjuan Gu, Shiwei Cui, Zhiqiang Lu, Xiao-Ying Li · 发表于：BMJ Open · 年份：2018 · DOI：10.1136/bmjopen-2018-021768 · 被引用次数：344 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Bariatric Surgery and Outcomes、Diabetes Management and Research

OBJECTIVE: Type 2 diabetes mellitus is increasing in young adults, and greater adiposity is considered a major risk factor. However, whether there is an association between obesity and diabetes and how this might be impacted by age is not clear. Therefore, we investigated the association between body mass index (BMI) and diabetes across a wide range of age groups (20-30, 30-40, 40-50, 50-60, 60-70 and ≥70 years old). DESIGN: We performed a retrospective cohort study using healthy screening programme data. SETTING: A total of 211 833 adult Chinese persons >20 years old across 32 sites and 11 cities in China (Shanghai, Beijing, Nanjing, Suzhou, Shenzhen, Changzhou, Chengdu, Guangzhou, Hefei, Wuhan, Nantong) were selected for the study; these persons were free of diabetes at baseline. PRIMARY AND SECONDARY OUTCOME MEASURES: Fasting plasma glucose levels were measured and information regarding the history of diabetes was collected at each visit. Diabetes was diagnosed as fasting plasma glucose ≥7.00 mmol/L and/or self-reported diabetes. Patients were censored at the date of diagnosis or the final visit, whichever came first. RESULTS: increase in BMI (95% CI 1.22 to 1.24). Across all age groups, there was a linear association between BMI and the risk of incident diabetes, although there was a stronger association between BMI and incident diabetes in the younger age groups (age×BMI interaction, p<0.0001). CONCLUSIONS: An increased BMI is also independently associated with a higher ...