Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis

作者：Junling Yin, Min Peng, Yanyan Ma, Rui Guo, Weiying Lin · 发表于：Chemical Communications · 年份：2018 · DOI：10.1039/c8cc07398h · 被引用次数：146 · 研究领域：Lipid metabolism and biosynthesis、Photosynthetic Processes and Mechanisms、Metabolomics and Mass Spectrometry Studies

A robust fluorescent probe CTPA has been rationally designed for cancer diagnosis by monitoring lipid drop (LD) polarity and number variation. With the outstanding properties of CTPA, we have shown that the diagnosis of cancer can be achieved not only at the cellular levels but also in organs and living mice for the first time.