Low Wall Shear Stress Is Associated with Local Aneurysm Wall Enhancement on High-Resolution MR Vessel Wall Imaging

作者：Wang Xiao, Tiewei Qi, Shaofu He, Z. Li, San‐San Ou, Guo‐Nan Zhang, Xinman Liu, Zi‐Yi Huang, Liang Feng · 发表于：American Journal of Neuroradiology · 年份：2018 · DOI：10.3174/ajnr.a5806 · 被引用次数：45 · 研究领域：Intracranial Aneurysms: Treatment and Complications、Advanced MRI Techniques and Applications、Aortic aneurysm repair treatments

BACKGROUND AND PURPOSE: Some retrospective studies have found that the aneurysm wall enhancement on high-resolution MR vessel wall postgadolinium T1WI has the potential to distinguish unstable aneurysms. This study aimed to identify hemodynamic characteristics that differ between the enhanced and nonenhanced areas of the aneurysm wall on high-resolution MR vessel wall postgadolinium T1WI. MATERIALS AND METHODS: TOF-MRA and high-resolution MR vessel wall T1WI of 25 patients were fused to localize the enhanced area of the aneurysm wall. Using computational fluid dynamics, we studied the aneurysm models. Mean static pressure, mean wall shear stress, and oscillatory shear index were compared between the enhanced and nonenhanced areas. RESULTS: The aneurysmal enhanced area had lower wall shear stress ( P < .05) and a lower oscillatory shear index ( P = .021) than the nonenhanced area. In addition, the whole aneurysm had lower wall shear stress ( P < .05) and a higher oscillatory shear index ( P = .007) than the parent artery. CONCLUSIONS: This study suggests that there are hemodynamic differences between the enhanced and nonenhanced areas of the aneurysm wall on high-resolution MR vessel wall postgadolinium T1WI.